Gregg L Semenza Selected Research

Hypoxia (Hypoxemia)

6/2022	Regulation of Erythropoiesis by the Hypoxia-Inducible Factor Pathway: Effects of Genetic and Pharmacological Perturbations.
6/2022	Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment.
1/2022	HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia.
1/2022	Hypoxia-inducible factors: cancer progression and clinical translation.
1/2022	Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis.
11/2021	Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
1/2021	Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1.
1/2021	Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors.
1/2021	Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
1/2019	HIF-1α is required for development of the sympathetic nervous system.

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Gregg L Semenza Research Topics

Disease

172	Hypoxia (Hypoxemia) 06/2022 - 01/2002
84	Neoplasms (Cancer) 01/2022 - 01/2002
42	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2002
32	Neoplasm Metastasis (Metastasis) 01/2022 - 03/2003
18	Ischemia 12/2016 - 01/2003
9	Carcinogenesis 11/2021 - 01/2004
8	Triple Negative Breast Neoplasms 01/2018 - 01/2012
7	Retinal Neovascularization 01/2021 - 06/2010
7	Hypertension (High Blood Pressure) 01/2018 - 09/2007
6	Carcinoma (Carcinomatosis) 01/2016 - 10/2002
6	Pulmonary Hypertension 07/2015 - 01/2004
5	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016 - 01/2003
5	Vascular Remodeling 01/2016 - 03/2004
5	Wounds and Injuries (Trauma) 10/2011 - 11/2008
4	Apnea 01/2017 - 09/2007
4	Renal Cell Carcinoma (Grawitz Tumor) 10/2014 - 07/2005
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2014 - 07/2006
4	Polycythemia (Erythrocytosis) 05/2010 - 12/2002
4	Prostatic Neoplasms (Prostate Cancer) 10/2009 - 01/2004
3	Sickle Cell Anemia (Hemoglobin S Disease) 01/2021 - 12/2016
3	Sleep Apnea Syndromes (Sleep Apnea) 01/2017 - 07/2013
3	Vascular Diseases (Vascular Disease) 01/2017 - 05/2010
3	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2017 - 11/2013
3	Infections 01/2017 - 09/2013
3	Eye Diseases (Eye Disease) 06/2015 - 09/2013
3	Burns 10/2011 - 03/2010
3	Lymphoma (Lymphomas) 02/2010 - 03/2007
3	Colonic Neoplasms (Colon Cancer) 12/2008 - 10/2002
2	Anemia 06/2022 - 01/2019
2	Chronic Renal Insufficiency 06/2022 - 01/2019
2	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 10/2014
2	Uveal melanoma 03/2021 - 02/2016
2	Blindness (Hysterical Blindness) 01/2021 - 01/2017

Drug/Important Bio-Agent (IBA)

64	Hypoxia-Inducible Factor 1IBA 03/2021 - 01/2002
45	Oxygen (Dioxygen)IBA 06/2022 - 01/2002
44	Proteins (Proteins, Gene)FDA Link 11/2021 - 10/2002
33	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2002
27	Transcription Factors (Transcription Factor)IBA 01/2022 - 03/2003
22	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2002
22	Messenger RNA (mRNA)IBA 01/2019 - 01/2003
21	EnzymesIBA 01/2021 - 02/2002
15	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 12/2006
10	CytokinesIBA 01/2017 - 01/2005
10	Digoxin (Digitek)FDA LinkGeneric 03/2014 - 12/2008
9	Lactic Acid (Lactate)FDA LinkGeneric 11/2012 - 03/2006
8	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 06/2022 - 02/2005
8	Erythropoietin FDA Link 06/2022 - 07/2003
8	Retinaldehyde (Retinal)IBA 01/2017 - 06/2010
7	Small Interfering RNA (siRNA)IBA 07/2015 - 03/2003
7	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/2010 - 11/2003
6	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2003
6	CollagenIBA 01/2022 - 09/2011
6	CatecholaminesIBA 01/2018 - 01/2006
6	AngiopoietinsIBA 01/2017 - 09/2012
6	Pharmaceutical PreparationsIBA 01/2017 - 10/2006
6	Pyruvic Acid (Pyruvate)IBA 09/2014 - 03/2006
5	AntioxidantsIBA 01/2018 - 09/2007
5	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 07/2008
4	LigandsIBA 11/2021 - 07/2005
4	Interleukin-6 (Interleukin 6)IBA 10/2018 - 05/2011
4	NADP (NADPH)IBA 10/2017 - 11/2011
4	AnthracyclinesIBA 04/2017 - 07/2008
4	AcriflavineIBA 01/2017 - 10/2009
4	Protein Isoforms (Isoforms)IBA 09/2014 - 11/2006
4	Daunorubicin (Cerubidine)FDA LinkGeneric 12/2013 - 07/2008
3	Prolyl-Hydroxylase InhibitorsIBA 06/2022 - 06/2013
3	CalciumIBA 11/2021 - 02/2008
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2004
3	Glutamine (L-Glutamine)FDA Link 01/2019 - 09/2013
3	Gemcitabine FDA Link 01/2018 - 12/2014
3	Serine (L-Serine)FDA Link 01/2017 - 01/2016
3	Estrogen ReceptorsIBA 01/2016 - 03/2003
3	Pyruvate KinaseIBA 10/2015 - 07/2011
3	Phosphotransferases (Kinase)IBA 12/2014 - 10/2002
3	CystathionineIBA 10/2014 - 03/2012
3	Fatty Acids (Saturated Fatty Acids)IBA 09/2014 - 09/2013
3	LuciferasesIBA 03/2014 - 05/2009
3	Endothelin-1 (Endothelin 1)IBA 04/2013 - 03/2004
3	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 10/2012 - 11/2003
3	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 09/2012 - 09/2011
3	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 02/2010 - 03/2006
3	IronIBA 07/2009 - 09/2006
2	Aldehyde DehydrogenaseIBA 11/2021 - 01/2018
2	ChromatinIBA 01/2021 - 10/2013
2	Histones (Histone)IBA 01/2021 - 12/2012
2	Neutralizing AntibodiesIBA 01/2020 - 03/2003
2	Protein Kinase CIBA 01/2019 - 10/2018
2	GlutaminaseIBA 01/2019 - 01/2016
2	Glutamic Acid (Glutamate)FDA Link 01/2019 - 10/2014
2	Adenosine (Adenocard)FDA LinkGeneric 10/2018 - 01/2016
2	superoxide dismutase 2IBA 01/2018 - 05/2013
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2018 - 12/2014
2	Carboplatin (JM8)FDA LinkGeneric 01/2018 - 01/2017
2	Glutathione (Reduced Glutathione)IBA 10/2017 - 08/2015

Therapy/Procedure

37	Therapeutics 01/2022 - 01/2002
18	Drug Therapy (Chemotherapy) 01/2021 - 02/2009
5	Radiotherapy 12/2016 - 12/2002
3	Immunotherapy 01/2022 - 01/2020
3	Surgical Amputation (Amputations) 02/2016 - 10/2009
3	Lung Transplantation 01/2014 - 06/2011